The software is available under an open-source license. The PCluster can be accessed from Piraña, and both software products have extensively been tested on a large academic network. A daemon script, written in Perl, was designed to run in the background on each node in the cluster, and to manage job distribution. The cluster supports the modeling toolkit Perl speaks NONMEM (PsN), and can include dedicated or non-dedicated PCs. This platform is easy to set up, runs in standard network environments, and can be extended with additional nodes if needed. (BTW, I know there are debates about the usefulness or otherwise of VPC plots. A solution to this problem is offered here, called PCluster. The VPC is a model diagnostic procedure for the observed data and provides a visual check of whether the model is capturing central tendencies and dispersion in our data. Modeling with NONMEM is computationally burdensome, which may be alleviated by distributing runs to computer clusters. Through the secure shell (SSH) protocol, Piraña can also be used to connect to Linux clusters (SGE, MOSIX) for distribution of workload. Piraña provides features for the management and creation of model files, the overview of modeling results, creation of run reports and handling of datasets and output tables, and the running of custom R scripts on model output. A graphical user interface, Piraña, was developed that offers a complete modeling environment for NONMEM, enabling both novice and advanced users to increase efficiency of their workflow. Pharmacokinetic–pharmacodynamic modeling using non-linear mixed effects modeling (NONMEM) is a powerful yet challenging technique, as the software is generally accessed from the command line.
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